Program Management Team
M. Ameloot, I. Lambrichts, J.-M. Rigo , B. Brône
Coordinator: Marcel Ameloot
The bioimaging domain aims to contribute to the recognition of BIOMED at the scientific and innovation level through advanced imaging methods and protocols offered to the other research domains. The aimed recognition in the field of imaging microscopy, especially through the label-free approach and the tracking of nanoparticles, should allow to play a role in the current open innovation model of the pharmaceutical industry.
Specific research focus
ex vivo 3D-fluorescence microscopy of organ slices and tissues
Develop in vivo 3D-fluorescence microscopy of parts of the brain of small animals
Utilize and improve label-free 3D-microscopy
- based on the autofluorescence of cells, tissues and organs without exogenous labels or transfection with fluorescent proteins
- based on nonlinear optical processes in cells, tissues and organs.
- specific for stem cell research, tissue engineering and regenerative medicine.
- for the characterization of the cellular localization and dynamic behavior of nanoparticles within the context of biomarkers, nanomedicine and toxicology
Combine fluorescence microscopy imaging methods with electrophysiological approaches in ex vivo measurements on living brain slices
Retrieve sub-cellular (3D)-localization of specific molecules / biomarkers / receptors with cryo-TEM and 3D-EM tomography