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Persmededeling 2/02/2012

World première UHasselt: first 3D-printed lower jaw implant

wereldprimeur aan de UHasselt The University of Hasselt has come out with a world première: The Functional Morphology research group of the UHasselt BIOMED research institute has created the method behind the very first customised 3D-printed lower jaw. The implant procedure was carried out a few months ago on an 83-year old patient with a serious jaw infection. This procedure rescued important vital functions (breathing, speech, chewing, sensation) as well as the aesthetic aspect that would otherwise have been lost. BIOMED worked on this project with the Xios College, the Catholic University of Leuven, the Oral- and Maxillofacial Surgeons of the Orbis Medical Centre Sittard-Geleen (the Netherlands), SIRRIS ├ Collective Centre of the Belgian Technology Industry, Xilloc Medical BV (Maastricht, the Netherlands ├ 3D design) and LayerWise NV (Leuven ├ Production). This is the first time that a complete lower jaw has been replaced in a patient. The 3D printing technique using a powdered metal is ideally suited for producing this type of patient-specific implant. The fact that the technique can now be used for a complete lower jaw implant is unique. ┐The introduction of printed implants can be compared to man┌s first venture on the moon: a cautious, but firm step,└ says Professor Jules Poukens of BIOMED.

Unique method
A 83 year old patient suffered from a long lasting and rapidly progressive infection of almost the entire mandible with a large wound in her face. In order to retain an open airway, function of swallowing and chewing, surgical removal of the entire mandible was necessary to cure the patient.
The classical treatment, by only removing the damaged bone, would result in a small mandible without any support and function. Another possibility  was complex microsurgical reconstruction with prolonged operation time and  hospital stay. Taking the age of the patient in consideration, the choice was made to reconstruct the entire mandible with a custom made 3D printed implant.
Hence, the patient was spared a long surgery and  the temporo-mandibular joint could be restored at the same time. This treatment is unique regarding the fact that it is the first 3D printed custom made implant for replacement of the entire mandible. This innovative method of manufacturing by using 3D printing of titanium powder is quite unique.

Doctors and engineers together around design computer and operation table
This new treatment approach was developed at the Morphology group, Biomed Research Institute, University of Hasselt, Belgium (Prof. dr. Jules Poukens, Prof. dr. Ivo Lambrichts, Dr. Ingeborg van Kroonenburgh) in cooperation with engineers from Xios University College (Dr. Ir. Michäel Daenen), SIRRIS (ir. Carsten Engel), Xilloc Medical BV, Maastricht, The Netherlands (ing. Maikel Beerens), department Medical Engineering of the University of Leuven, Belgium (Prof. dr. Jos Vander Sloten) and the department of Cranio-, Maxillo-Facial surgery of Orbis Medical Center Sittard-Geleen, The Netherlands. The manufactering by additive technology, a specific form of 3D printing, was performed by LayerWise, Leuven, Belgium(Dr. Ir. Peter Mercelis, Ir. Ruben Wauthlé).

LayerWise NV from Leuven (Dr. Peter Mercelis, Dr. Ruben Wauthlé) produced the titanium implant using additive Laser Melting technology, a specific form of 3D printing. The design, processing and production of the implant were all done digitally.  ┐Computer technology will cause a veritable revolution in the medical world. We just need to learn to work with it,└ added Professor Jules Poukens. ┐Doctors and engineers together around the design computer and the operation table: that┌s what we call being truly innovative.└

The implant weighs approximately 107 grams. This is just a little bit heavier than a ─natural┌ lower jaw, but it┌s certainly not a problem. With other methods it can take up to two days before an implant is completely ready. With 3D printing, it was ready in just a couple of hours. The implant was coated with plasma sprayed artificial bone (hydroxy-apatite bone substitute compound) by Cambioceramics, Leiden, The Netherlands. Some anatomical parts, such as the condylar heads and the rims for the mandibular nerves were polished. Fixture sites for future prosthetic superstructures were incorporated.

Normal function with adequate speech, swallowing after 1 day
The patient underwent surgery in general anesthesia in June 2011. During surgery the inflammatory mandible was removed and replaced by the pre-operative manufactured custom implant. The contour of the face could be restored at the operation. On the first day after surgery, the patient showed already normal function with adequate speech, swallowing and unrestricted mandibular movement. Initially the recovery of the wound proceeded slowly but  the wound healed properly through use of  appropriate antibiotics.

Multidisciplinary collaboration
Patient specific implants are an excellent addition to current treatment options and will be used more and more in the future for repair of bony defects. The development of this unique implant was part of a multidisciplinary collaboration between multiple institutions in different countries. This partnership was awarded the grant of best innovation in the field of 3D printing on the RapidPro conference last week.

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