Program Management Team
Sven Hendrix, Marcel Ameloot , Bert Brône, Niels Hellings, Ivo Lambrichts, Jean-Michel Rigo, Veerle Somers
Coordinator: Sven Hendrix
This program focuses on the neurobiology of development and ageing. A central aim is to unravel the molecular and cellular interactions leading to complex patterning in the developing and regenerating brain. We study in particular plasticity of excitability as well as neurite growth in health and regeneration. Our long-term goal is to apply these concepts to the ageing brain and to develop reliable biomarkers for life-long fitness of the CNS as well as new therapies for CNS diseases such as traumatic CNS injury and epilepsy.
Specific research focus
Study the influence of neurotransmitters on the development of interneurons and projection neurons in the cortex
Decipher the developmental patterns of microglial invasion of the embryonic CNS
Determine the interaction of microglial and neuronal cells in the embryonic brain
Characterize the functional properties of newborn neurons in the hippocampal network in epileptic models (ionotropic neurotransmitter receptors and neuropeptides)
Study the activation phenotype of microglia in animal models of multiple sclerosis
Promote axon growth and regeneration by digesting inhibitory extracellular matrix with endogenous proteases
Use vascularization strategies to improve histological & functional recovery after CNS injury
Determine the influence of cholesterol metabolism on de- and remyelination
Use stem cell technology to support CNS regeneration in the central and peripheral nervous system.