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THESIS DR. RONALD THOELEN - SYNOPSIS

"A MIP ,Molecularly Imprinted Polymers, based impedimetric sensor for the detection of small MW molecules"
The urge of detecting small molecules for biomedical, environmental and chemical purposes is huge. By mimicking the selectivity and sensitivity of biological systems, synthetic materials with imprinted nano-cavities can act as highly selective tailor-made artificial receptors. Implementing these materials in a piezoelectric or electrochemical sensing device can offer fast and straight-forward detection together with high sensitivity and device miniaturization. The highly selective imprinting material is made by adding the target molecule to a polymer matrix of polymethacrylic acid (PMAA) and hardening this solution with UV. These molecularly imprinted polymers, MIPs, can be synthesised for almost any molecule. By implementing these MIPs in an electronic sensing design the specific recognition by the MIPs can be converted in a measurable signal. Using this technique L-nicotine and histamine could be detected in the submicromolar range and the sensor could distinguish L-nicotine from the resembling molecule L-cotinine, which differs only one oxygen atom. As a fast, easy-to-use sensor with electric readout, the MIP-based impedimetric sensor could be useful for the detection of small molecules in the pharmaceutical, environmental, diagnostic and biotechnological sector.