All biosensing activities follow the principle of label-free detection in the natural matrix of the molecules under study and make use of novel materials such as conjugated polymers and wide-bandgap materials in the context of emerging bioanalytical techniques. The most important readout techniques are electrochemical impedance spectroscopy and microbalances, while we also employ reference techniques such as ELISA tests, microfluorescense, optical spectroscopy, cyclic voltammetry, and constant-capacity techniques. Globally, we aim at user friendly, economical sensor concepts, which can easily be applied in field studies or point-of-care diagnostics. Important assets in this are the renowned expertise in covalent linking techniques between bio receptors and sensor surfaces as well as the development of stable and specific synthetic receptors.
i) Characterization of DNA fragments with respect to single-nucleotide polymorphisms,
ii) Detection of cardiovascular disease markers in human blood serum,
iii) Detection of small, pharmaceutically relevant molecules in various matrices, which also opens up applications in food safety and environmental monitoring,
iv) Development of recognition- and characterization systems for blood cells,
v) Polyfunctional micro- and nanoparticles for biomagnetic separation and intracellular diagnostics and drug delivery.