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Details research group Cardio & organ systems (COST)


Expertise of the research group :

The Cardiology and Organ Systems (COST) research group focuses on in vitro and in vivo cellular and animal models in different fields such as cardiovascular disease, oncology and neurological disorders. These include the use of different stem cell types (embryonal, iPSC, DPSC, CASCs) and animal models of diastolic and systolic heart failure, cancer, peripheral neuropathies and ischemic stroke. These models are used to design and develop therapeutic applications in e.g. cancer and myocardial infarction or to unravel underlying disease mechanisms e.g. the role of AGEs and extracellular vesicles in cardio- and cerebrovascular disease. In addition to (stem) cell-based therapies, the effect of exercise as a medicine to improve the cardiometabolic status in various neurodegenerative, cardiovascular and respiratory diseases as well as in diabetes is studied. In general, the underlying biomedical/biomolecular mechanisms are investigated in animal models and human subjects using proteomic, genomic and bionanotechnology approaches.  This enables us to identify biomarker signatures (e.g. extracellular vesicles containing biomarkers) associated with the disease status or to monitor successful therapies. Thanks to the close collaboration with Reval, the Jessa Hospital and ZOL, we have the unique opportunity to combine basic research and clinical research and to translate acquired knowledge into clinical practice

Keywords :
  • Advanced glycation end products
  • Angiogenesis
  • Cancer
  • Cardiovascular disease
  • Diabetes
  • Exercise intervention
  • Extracellular vesicles
  • Heart Ischemia
  • Ischemic stroke
  • Stem cells

Responsible :
Luc MICHIELS

Members of the research group :

Ruth ACHTEN
Lotte ALDERS
Koen AMELOOT
Yoann BATAILLE
Evert BATEN
Amy BELBA
Johan BELLEMANS
Philippe BERTRAND
Virginie BITO
Annelies BRONCKAERS
Pieter CAEKEBEKE
Marithe CLAES
Jade CLAESSENS
William COLYN
Sarah D'HAESE
Jeroen DAUW
Helene DE CANNIERE
Sebastien DEFERM
Michiel DELESIE
Dorien DELUYKER
Paul DENDALE
Jo DENS
Eefje DERCON
Elien DERVEAUX
Lien DESTEGHE
Sarah DEVILLE
Inge DIERICKX
Pauline DREESEN
Ronald DRIESEN
Ward EERTMANS
Lize EVENS
Maarten FALTER
Pascal GERVOIS
Olivier GHEKIERE
Chelsea GRAHAM
Henri GRUWEZ
Wilfried GYSELAERS
Sibren HAESEN
Hein HEIDBUCHEL
Lara HEMERYCK
Marc HENDRIKX
Lieven HERBOTS
Florian HERMANS
Line HEYLEN
Petra HILKENS
Sarah HOEDEMAKERS
Michiel JACOBS
Marc JANS
Hanne JEURISSEN
Abdullah KAYA
Charly KEYTSMAN
Lieselotte KNAEPEN
Joep KNOL
Pieter KOOPMAN
Ganesh KUMARASAMY
Soren KUYPERS
Ivo LAMBRICHTS
Dorien LANSSENS
Karen LIBBERECHT
Melissa LO MONACO
Joy LODEWIJCKX
Didier MALAMBA LEZ
Hanne MARIËN
Jeroen MEBIS
Evelyne MEEKERS
Liesbet MESOTTEN
Luc MICHIELS
Amanda MOYA GOMEZ
Wilfried MULLENS
Revathy MUNUSWAMY
Ine NIESTE
Petra NIJST
Kim NIJSTEN
Rana ONDER
Bert OP 'T EIJNDE
Elke PIRLET
Laurent PISON
Constantinus POLITIS
Laura PONSAERTS
Jules POUKENS
Iris RENIERS
Jolien ROBIJNS
David RUTTENS
Jeanine SANTERMANS
Martijn SCHERRENBERG
Melanie SCHOUTTETEN
Gregory SERGEANT
Gitte SLINGERS
Christophe SMEETS
Dandan SONG
Jan SPAAS
Job STOKS
Kristof THEVISSEN
Michiel THOMEER
Kaihara TOSHIKI
Jolien VAN DEN BOSCH
Kurt VAN DER SPEETEN
Evelyne VAN KERCKHOVE
Koenraad VAN RENTERGHEM
Wendy VANDENDRIES
Pieter VANDERVOORT
Tim VANGANSEWINKEL
Frederik VERBRUGGE
Jan VERWERFT
Johan VIJGEN
Pascal VRANCKX
Koen WILLEKENS
Esther WOLFS
Femke WOUTERS
Renate ZEEVAERT



Projects of the research group 


Publications of the research group