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Details research group Cardio & organ systems (COST)


Expertise of the research group :

The Cardiology and Organ Systems (COST) research group focuses on in vitro and in vivo cellular and animal models in different fields such as cardiovascular disease, oncology and neurological disorders. These include the use of different stem cell types (embryonal, iPSC, DPSC, CASCs) and animal models of diastolic and systolic heart failure, cancer, peripheral neuropathies and ischemic stroke. These models are used to design and develop therapeutic applications in e.g. cancer and myocardial infarction or to unravel underlying disease mechanisms e.g. the role of AGEs and extracellular vesicles in cardio- and cerebrovascular disease. In addition to (stem) cell-based therapies, the effect of exercise as a medicine to improve the cardiometabolic status in various neurodegenerative, cardiovascular and respiratory diseases as well as in diabetes is studied. In general, the underlying biomedical/biomolecular mechanisms are investigated in animal models and human subjects using proteomic, genomic and bionanotechnology approaches.  This enables us to identify biomarker signatures (e.g. extracellular vesicles containing biomarkers) associated with the disease status or to monitor successful therapies. Thanks to the close collaboration with Reval, the Jessa Hospital and ZOL, we have the unique opportunity to combine basic research and clinical research and to translate acquired knowledge into clinical practice

Keywords :
  • Advanced glycation end products
  • Angiogenesis
  • Cancer
  • Cardiovascular disease
  • Diabetes
  • Exercise intervention
  • Extracellular vesicles
  • Heart Ischemia
  • Ischemic stroke
  • Stem cells

Responsible :
Luc MICHIELS

Members of the research group :

Ruth ACHTEN
Koen AMELOOT
Evert BATEN
Hanne BELIEN
Johan BELLEMANS
Niels BELMANS
Philippe BERTRAND
Virginie BITO
Annelies BRONCKAERS
Pieter CAEKEBEKE
William COLYN
Jeroen DAUW
Caro DAUW
Helene DE CANNIERE
Bart DE MOOR
Sebastien DEFERM
Michiel DELESIE
Dorien DELUYKER
Paul DENDALE
Jo DENS
Eefje DERCON
Elien DERVEAUX
Lien DESTEGHE
Sarah DEVILLE
Inge DIERICKX
Yorg DILLEN
Pauline DREESEN
Ronald DRIESEN
Wannes DUPONT
Ward EERTMANS
Lize EVENS
Laura FERREIRA PINHEIRO NICOLIELO
Pascal GERVOIS
Olivier GHEKIERE
Kristof GOVAERTS
Chelsea GRAHAM
Wilfried GYSELAERS
Sibren HAESEN
Hein HEIDBUCHEL
Marc HENDRIKX
Florian HERMANS
Line HEYLEN
Petra HILKENS
Marc JANS
Abdullah KAYA
Hannelore KEMPS
Lieselotte KNAEPEN
Pieter KOOPMAN
Soren KUYPERS
Ivo LAMBRICHTS
Dorien LANSSENS
Karen LIBBERECHT
Melissa LO MONACO
Joy LODEWIJCKX
Didier MALAMBA LEZ
Hanne MARIEN
Kristel MARQUET
Guy MASSA
Jeroen MEBIS
Greet MERCKX
Liesbet MESOTTEN
Luc MICHIELS
Amanda MOYA GOMEZ
Wilfried MULLENS
Revathy MUNUSWAMY
Ine NIESTE
Petra NIJST
Jean-Paul NOBEN
Bert OP 'T EIJNDE
Jules POUKENS
Jessica RATAJCZAK
Iris RENIERS
Jolien ROBIJNS
Jeanine SANTERMANS
Martijn SCHERRENBERG
Melanie SCHOUTTETEN
Gregory SERGEANT
Gitte SLINGERS
Christophe SMEETS
Kristof SMEETS
Jan SPAAS
Job STOKS
Kristof THEVISSEN
Michiel THOMEER
Kurt VAN DER SPEETEN
Evelyne VAN KERCKHOVE
Koenraad VAN RENTERGHEM
Pieter VANDERVOORT
Tim VANGANSEWINKEL
Karolien VANHOVE
Maxim VERBOVEN
Frederik VERBRUGGE
Pascal VRANCKX
Koen WILLEKENS
Esther WOLFS



Projects of the research group 


Publications of the research group