||Identification and quantification of single molecules and their conformational changes have
important applications to chemistry, biology and physics. Quantum operational principles bring new
philosophy into sensing of atomistic objects by providing non-invasive interaction platform. By the
principle, they allow imaging of spins in single atoms or molecules and their electric or magnetic
fields without need of averaging over large ensembles. They can give information about quantum
inter-correlations of individual objects and insight into measured matter, not accessible by classical
ways. Colour centres in diamond, such as NV or SiV, gained important momentum for quantum
imaging of single atomistic objects. However there is no way how to engineer by a controllable
manner single-site colour centres in diamond without generating another point defects, reducing
the lattice relaxation and spin coherence and times T1 and T2. Implantation techniques generate
inherently defects and have a limited yield. CVD technology does not allow controlling point defects
on an atomic precision scale. We attempt to build colour probes by a new method deterministically
by embedding them in he smallest diamond precursors: individual cages of diamondoid molecules.
We also explore single-crystal CVD diamond engineering by molecular functionalization and CVD
and overgrowth with predefined centres rather then incorporating them during the growth, giving
an ultimate spin control for advanced applications.