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JEROME HENDRIKS - MACROPHAGE LIPID METABOLISM LAB

"PROMOTING BRAIN REPAIR BY HARNESSING THE IMMUNE SYSTEM"


Our current research aims at elucidating the impact of disturbed lipid metabolism on inflammatory and repair processes within the central nervous system (CNS) with a focus on Multiple Sclerosis (MS).

During MS macrophages infiltrate the CNS and degrade the myelin sheath surrounding axons which is called demyelination. As myelin is essential for nerve conduction, demyelination leads to conduction failure and clinical symptoms such as loss of vision and muscle weakness.

Myelin consists for the major part of lipids, such as cholesterol and fatty acids, that also have important immune regulatory functions. In MS, a disturbed lipid metabolism is detected. However, little is known about the cause of this disturbance and the impact it has on disease progression.

We aim to:
1) determine the role of cholesterol and fatty acids in CNS inflammation, demyelination and repair of damaged myelin sheaths (remyelination).
2) study how dietary components affect CNS lipid metabolism and the function of resident brain cells.

Experimental autoimmune encephalomyelitis (EAE): mouse model of CNS inflammation

Cuprizone model: mouse model of de- and remyelination

Organotypic brain slice cultures- ex vivo model of remyelination

Primary cell cultures of oligodendrocytes, microglia and astrocytes

Macrophage inflammatory and metabolic phenotyping

Dr. Jeroen Bogie

As a PhD student at Hasselt University, Jeroen Bogie defined the physiology of macrophages in multiple sclerosis (MS). He established thatmyelin-containing macrophages suppress autoreactive T cell proliferation andthat lipid-sensing nuclear receptors are key in driving the functionalproperties of macrophages in MS lesions. In 2014, he started a post-doctoralposition at Rotterdam University. Here, he assessed the impact of plant sterolson Alzheimer’s disease. In 2015, Jeroen obtained a FWO postdoctoral grant tocontinue on findings that emanated from his PhD project. Currently, he defines the impact of fatty acid metabolism on the functional properties of macrophagesand T cells in MS. 


Dr. Mansour Haidar

Mansour obtained an MSc in neuroscience from the University of Strasbourg in France, and a PhD in biochemistry and biotechnology from the University of Antwerp in Belgium. During his PhD he studied autophagy and proteostasis in neurodegeneration. He joined the group end of 2018 bringing with him this expertise to the field of neuroinflammation and macrophage metabolism. 


PhD students

Elien Grajchen


Aida Garcia Corrales


Tess Dierckx


Sam Vanherle


Melanie Loix

 


Technicians

Marie-Paule Tulleners


Laura Dusaer

 

 

 

Jeroen F.J. Bogie , Elien Grajchen , Elien Wouters , Aida Garcia Corrales , Tess Dierckx , Sam Vanherle , Jo Mailleux , Pascal Gervois,  , Esther Wolfs , Jonas Dehairs , Jana Van Broeckhoven, , Andrew P. Bowman, Ivo Lambrichts , Jan-Åke Gustafsson , Alan T. Remaley, Monique Mulder, Johannes V. Swinnen , Mansour Haidar, Shane R. Ellis , James M. Ntambi , Noam Zelcer, Jerome J.A. Hendriks. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. J Exp Med (2020) 217 (5): e20191660. (IF 10.9)

 

Bogie JFJ, Haidar M, Kooij G*, Hendriks JJA*. Fatty acid metabolism in the progression and resolution of CNS disorders. Adv Drug Deliv Rev. 2020 Jan 25. pii: S0169-409X(20)30006-5. doi: 10.1016/j.addr.2020.01.004. (IF15.6) *equal contribution

 

Wouters E*, de Wit NM*, Vanmol J, van der Pol SMA, van Het Hof B, Sommer D, Loix M, Geerts D, Gustafsson JA, Steffensen KR, Vanmierlo T, Bogie JFJ, Hendriks JJA*, de Vries HE*. Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function. Front Immunol. 2019 Jul 31;10:1811. doi: 10.3389/fimmu.2019.01811. (IF 4.7) *equal contribution.

 

Grajchen E, Hendriks JJA, Bogie JFJ. The physiology of foamy phagocytes in multiple sclerosis. Acta Neuropathol Commun. 2018 Nov 19;6(1):124 doi: 10.1186/s40478-018-0628-8. Review. (IF 5.36)

 

Jo Mailleux,  Silke Timmermans,  Katherine Nelissen,  Jasmine Vanmol,  Tim Vanmierlo,  Jack van Horssen, Jeroen FJ Bogie and  Jerome JA Hendriks. Low-density lipoprotein receptor deficiency attenuates neuroinflammation through the induction of apolipoprotein  Front Immunol. 2017 Nov 30;8:1701. doi: 10.3389/fimmu.2017.01701. (IF 4.7)

 

Mailleux J, Vanmierlo T, Bogie JF, Wouters E, Lütjohann D, Hendriks JJA*, van Horssen J*. Active liver X receptor signaling in phagocytes in multiple sclerosis lesions. Mult Scler. 2017 Feb 1 (IF 4.8) *equal contribution

 

Jorissen W, Wouters E, Bogie JF, Vanmierlo T, Noben JP, Sviridov D, Hellings N, Somers V, Valcke R, Vanwijmeersch B, Stinissen P, Mulder MT, Remaley AT, Hendriks JJA. Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL. Sci Rep. 2017 Feb 23;7:43410. (IF 4.2)

 

Vanmierlo T, Bogie J, Mailleux J, Vanmol J, Lütjohann D, Mulder MT, Hendriks JJA. Plant sterols: friend or foe in CNS disorders? Progress in Lipid Research 2015 (IF 13.0)

 

Bogie JF, Stinissen P, Hendriks JJA. Macrophage subsets and microglia in multiple sclerosis. Acta Neuropathol. 2014 Aug;128(2):191-213. (IF 10.7)

 

Timmermans S, Bogie JF, Vanmierlo T, Lütjohann D, Stinissen P, Hellings N, Hendriks JJA. High Fat Diet Exacerbates Neuroinflammation in an Animal Model of Multiple Sclerosis by Activation of the Renin Angiotensin System. J Neuroimmune Pharmacol. 2013 Sep 26. (IF 3.8)

 

Myelin alters the inflammatory phenotype of macrophages by activating PPARs. Bogie JFJ, Jorissen  W, Mailleux  J, Nijland PG, Zelcer  N, Vanmierlo  T, Van Horssen  J, Stinissen  P, Hellings  N, Hendriks JJA. Acta Neuropathol Commun. 2013 Aug 2;1(1):43. (IF 5.36)

 

Bogie JF, Timmermans S, Huynh-Thu V, Irrthum A, Smeets HJM, Gustafsson JA, Steffensen KR, Mulder MT, Stinissen P, Hellings N, Hendriks JJA. Myelin-Derived Lipids Modulate Macrophage Activity by Liver X Receptor Activation. PLoS One. 2012;7(9):e44998. (IF 3.8)