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VIRGINIE BITO - LABORATORY FOR CARDIOVASCULAR PHYSIOLOGY

"GET RIGHT TO THE HEART OF THE MATTER: FINDING THE UNDERLYING MECHANISMS IN CARDIOVASCULAR DISEASES"


Heart failure (HF) is a leading cause of mortality and morbidity worldwide affecting ~2% of the worldwide population. HF is defined as the inability of the heart to meet the energy demand of the body. Current therapeutic approaches can slow down but not stop the progression of HF. Therefore, our research is focused on finding the underlying mechanisms leading to HF. So that patients suffering from cardiovascular diseases can be cured in the future.

  • The role of Advanced Glycation End-Products (AGEs) in Cardiovascular Dysfunction
  • Exercise Intervention as a potential therapy for Diabetic Cardiomyopathy
  • Stem Cell transplantation as a new therapy for Myocardial Infarction
  • Chemotherapy-induced Cardiotoxicity

In vivo:

  •  Rat models of cardiac dysfunctions (e.g., myocardial infarction, cardiotoxicity, diabetic cardiomyopathy, …)
  •  Imaging of the heart (echocardiography with VisualSonics Vevo 3100)
  •  Transplantation of cardiac stem cells
  •  Hemodynamic measurements

In vitro:

  •  Isolation of adult rat cardiomyocytes (i.e. Langendorff set-up)
  •  Electrophysiology (i.e. Patch clamp)
  •  Fractional cell shortening measurements (Ionoptix systems)
  •  Studying contractile function of isolated aortic rings
  •  Isolation and culturing of cardiac stem cells

 

  

Prof. Dr. Virginie Bito P.I.

Dr. Dorien Deluyker  Post Doc

Dra. Lize Evens   PhD student

Drs. Sibren Haesen  PhD student

Dra. Hanne Beliën  PhD student

Cross-linking versus RAGE: How do high molecular weight advanced glycation products induce cardiac dysfunction? Deluyker D. et al – International Journal of Cardiology, 2016 – IF 6.19

 

Effect of Exercise Intervention on Cardiac Function in Type 2 Diabetes Mellitus: A Systematic Review.

Verboven M. et al – Sports Medicine, 2019 – IF 7.58

 

Cardiac atrial appendage stem cells engraft and differentiate into cardiomyocytes in vivo: A new tool for cardiac repair after MI.

Fanton Y. et al - International Journal of Cardiology, 2016 – IF 4.64

 

Reduced force generating capacity in myocytes from chronically ischemic, hibernating myocardium.

Bito V. et al – Circulation Research, 2007 – IF