"Excited about inhibition & moved by migration"
Our brain is an intriguing organ that gradually becomes more active and refined during its development.
It is not surprising that disruption of brain development through genetic and environmental factors leads to neurodevelopmental diseases such as autism spectrum disorder and schizophrenia.
Since proper neurodevelopment is driven by the complex interplay between neurons and microglia, we focus on the impact of genetic and environmental factors on these cells. A genetic risk factor for autism spectrum disorder, directly acting at neuronal networks, is the impaired glycine receptor signaling in the brain.
Environmental factors impact the highly dynamic immune cells of the brain: microglia. Using molecular, cellular and behavioral approaches, we aim to understand the normal and pathological brain development in order to identify new targets with therapeutic potential for neurodevelopmental disorders.
Prof. dr. Bert Brône
Prof. dr. Jean-Michel Rigo
Microglia research line
dr. Yeranddy A. Alpizar
Project title: Molecular mechanisms of microglial dynamics
Project title: Microglial dynamics in neurodevelopmental disorders
Project title: Microglia and synapses in neurodevelopmental disorders
Project title: TRPV4 in spinal cord injury
Project title: Diamond probes to study subcellular control of cytoskeletal rearrangement by temperature sensitive ion channels in microglia
Glycine receptor research line
dr. Elisabeth Piccart
Project title: Glycinergic modulation of midbrain signal integration in schizophrenia
Project title: Subcellular localisation and function of glycine receptor alpha 2
Project title: A closer look at brain inhibition and seizure susceptibility following embryonic DNA damage (collaboration with SCK-CEN)
Project title: Diamond probes to study subcellular control of cytoskeletal rearrangement by temperature sensitive ion channels in neurons
Project title: Microglial dynamics in neurodevelopmental disorders (co-supervisor)
Project title: Molecular mechanisms of microglial dynamics in neurodevelopmental disorders (co-supervisor)
Kinga Réka Tasnady
Project title: Gastrointestinal function, enteric neuron connectivity, and microbiome analysis in a mouse model for major mental illness
Both authors contributed equally
Smolders SMT, Kessels S, Vangesewinkel T, Rigo JM, Legendre P and Brone B. Microglia: Brain cells on the move. Progress in Neurobiology. (2019); [IF: 10,568 (2018)].
Molchanova SM, Comhair J, Karadurmus D, Piccart E, Harvey RJ, Rigo JM, Schiffmann SN, §Brone B and §Gall D. Tonically active alpha2 subunit-containing glycine receptors regulate the excitability of striatal medium spiny neurons. Front Mol Neurosci. (2018); 10 442 [IF: 3,720].
Comhair J, Devoght J, Morelli G, Harvey RJ, Briz V, Borrie SC, Bagni C, Rigo JM, Schiffmann SN, Gall D, §Brone B and §Molchanova SM. Alpha2-containing glycine receptors promote neonatal spontaneous activity of striatal medium spiny neurons and support maturation of glutamatergic inputs. Front Mol Neurosci. (2018); 11 380 [IF: 3,720].
Smolders SM, Swinnen N, Kessels S, Arnauts K, Smolders S, Le Bras B, Rigo JM, Legendre P and Brone B. Age-specific function of alpha5beta1 integrin in microglial migration during early colonization of the developing mouse cortex. Glia. (2017); 65 (7): 1072-1088 [IF: 5,846].
Morelli G, Avila A, Ravanidis S, Aourz N, Neve RL, Smolders I, Harvey RJ, §Rigo JM, §Nguyen L and §Brone B. Cerebral cortical circuitry formation requires functional glycine receptors. Cereb Cortex. (2017); 27 (3): 1863-1877 [IF: 6,559].
Morelli G, Even A, Gladwyn-Ng I, Le Bail R, Shilian M, Godin JD, Peyre E, Hassan BA, Besson A, Rigo JM, Weil M, Brone B and Nguyen L. P27(kip1) modulates axonal transport by regulating alpha-tubulin acetyltransferase 1 stability. Cell Rep. (2018); 23 (8): 2429-2442 [IF: 7,815].
Even A, Morelli G, Broix L, Scaramuzzino C, Turchetto S, Gladwyn-Ng I, Le Bail R, Shilian M, Freeman S, Magiera MM, Jijumon AS, Krusy N, Malgrange B, Brone B, Dietrich P, Dragatsis I, Janke C, Saudou F, Weil M and Nguyen L. Atat1-enriched vesicles promote microtubule acetylation via axonal transport. Sci Adv. (2019); 5 (12): eaax2705 [IF: 12.804 (2018)].
Stancu IC, Cremers N, Vanrusselt H, Couturier J, Vanoosthuyse A, Kessels S, Lodder C, Brone B, Huaux F, Octave JN, Terwel D and Dewachter I. Aggregated tau activates nlrp3-asc inflammasome exacerbating exogenously seeded and non-exogenously seeded tau pathology in vivo. Acta Neuropathol. (2019); 137 (4): 599-617 [IF: 18,174 (2018)].
Torre-Muruzabal T, Devoght J, Van den Haute C, Brone B, Van der Perren A and Baekelandt V. Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an alpha-synuclein based rat model for parkinson's disease. Acta Neuropathol Com. (2019); 7 (1): [IF: 5.883 (2019)].