Project R-6246

Magnetic field induced neuroprotective environment in post-Ischemic neuroinflammation after: cellular and molecular targets (Research)

Stroke is an acute, clinical neurologic deficit caused by a disturbance in the blood supply of the brain. The most frequent cause of stroke (80-85%) is a thromboembolism or an in situ thrombosis, blocking the blood circulation leading to a decrease in oxygen and nutrient delivery to the brain. Currently, there is only therapy for a limited number of patients and thus new treatment options are desperately needed. Preliminary data from our group already showed that application of magnetic field (MF) for 30 minutes, significantly improved functional outcome after ischemic stroke in mice/gerbils. Nevertheless, the mode of action is still unknown. As restoration of the blood flow is an important event in recovery after stroke, the first objective is to further identify the angiogenic events and proteins involved in the beneficial effects of MF on blood vessel development. In addition, as it has also been demonstrated that activation of microglia after neuronal injuries is key for the healing process, our second objective is to study the effect of MF on the phenotype of microglia, with special attention on the ion current profile.

01 September 2015 - 31 December 2017