Project R-7598

Systematic review of the prenatal exposure to air pollution and its effects on the placenta. (Research)

Fetal development is a crucial window of susceptibility in which exposure-related changes can be fixed on the molecular level, eventually leading to potential changes in metabolism. Molecular markers of exposure, susceptibility and effect are essential to provide information on how the environment can affect the fetal onset of diseases and need to be analysed in the appropriate matrix. The placenta serves as a gatekeeper between mother and fetus and lies in contact with maternal environmental stress factors throughout pregnancy. This temporary tissue thus forms an optimal non-invasive matrix to investigate omics-related aberrations correlated to in utero exposures.

01 December 2016 - 31 May 2017