Project R-13034

Using a novel pathway to timely wrap myelin in multiple sclerosis (Research)

Multiple sclerosis (MS) is the most common neurological disorder in young adults. It develops as a result of a coordinated autoimmune response against myelin, the insulating sheath around axons that guarantees fast and efficient signal transduction. To counteract demyelination, oligodendrocytes (OLGs) and their precursor cells (OPCs) initially help to repair the myelin layers, but this process gradually fails leading to disease progression. While MS treatment has revolutionized the last decade, there is no drug that directly boosts remyelination. This project is centered around a new pathway, recently discovered by us to be crucial for successful remyelination. By stimulating this pathway, we aim to induce differentiation of OPCs to myelinating OLGs, and thereby induce repair in context of MS.

01 October 2022 - 30 September 2025