Project R-16166

Collagen and ketone supplementation to improve joint and skeletal muscle health and quality of life in older adults during immobilization and rehabilitation (Research)

Low muscle mass is a risk factor for increased morbidity and is closely linked to functional decline in older adults. In addition, repeated episodes of short-term immobilization and the resulting acute muscle atrophy contribute to the development of sarcopenia and adverse clinical outcomes. Mechanistically, the loss of skeletal muscle mass is caused by an imbalance between the rates of synthesis and breakdown of myofibrillar proteins. Research indicates that ketones and collagen peptides can support muscle protein synthesis through various mechanisms. Therefore, in this study, we aim to investigate the effect of oral ketones and collagen peptides during immobilization and subsequent resistance training in older adults.

16 October 2025 - 31 March 2027