Project R-16559

The role of mito-nuclear communication during stem cell growth and neurodevelopment under environmental stress – a case study with tire wear particles (Research)

Mitochondria and the cell nucleus must communicate closely to regulate stem cell growth, metabolism, and gene expression. This mito-nuclear communication is especially important during brain development, yet its role under environmental stress conditions remains poorly understood. Disruptions in this signaling network can interfere with brain formation and function. One source of environmental stress is (nano)pollution, such as tire wear particles. These airborne pollutants can enter cells and interfere with key cellular functions, raising concerns about their impact on human health. This research investigates how exposure to tire wear particles affects mito-nuclear communication during stem cell growth and early neuronal development. We examine how these pollutants impair mitochondrial function, alter nuclear gene regulation, and disrupt the cell's energy balance. By clarifying these mechanisms in in vitro stem cell models, we aim to improve our understanding of how environmental exposures may contribute to neurodevelopmental disorders. This will support more accurate risk assessments and inform protective strategies—especially for vulnerable populations such as children—against long-term neurological effects.

01 October 2026 - 30 September 2030