Project R-16932

DNA free energy of interaction: physics and applications (Research)

DNA is perhaps the most important molecule in biology, carrying the genetic information of all living organisms. Its mechanical properties are crucial to many of the complex processes that regulate its interactions. Due to its unique chemical structure, these properties are complex and depend on the scale and environment studied, with thermal fluctuations also exerting a significant influence. This PhD combines thermodynamics and statistical mechanics, using analytical models and computer simulations to deepen understanding in both biological and physical contexts. In particular, we apply these principles to DNA-based biosensors, in which molecular interactions are converted into a measurable mechanical response. By understanding and controlling this response, we aim to guide the development of more effective biosensors for medical diagnostics.

16 August 2026 - 15 August 2030