Cardio & organ systems

Expertise

The Cardiology and Organ Systems (COST) research group focuses on in vitro and in vivo cellular and animal models in different fields such as cardiovascular disease, oncology and neurological disorders. These include the use of different stem cell types (embryonal, iPSC, DPSC, CASCs) and animal models of diastolic and systolic heart failure, cancer, peripheral neuropathies and ischemic stroke. These models are used to design and develop therapeutic applications in e.g. cancer and myocardial infarction or to unravel underlying disease mechanisms e.g. the role of AGEs and extracellular vesicles in cardio- and cerebrovascular disease. In addition to (stem) cell-based therapies, the effect of exercise as a medicine to improve the cardiometabolic status in various neurodegenerative, cardiovascular and respiratory diseases as well as in diabetes is studied. In general, the underlying biomedical/biomolecular mechanisms are investigated in animal models and human subjects using proteomic, genomic and bionanotechnology approaches.  This enables us to identify biomarker signatures (e.g. extracellular vesicles containing biomarkers) associated with the disease status or to monitor successful therapies. Thanks to the close collaboration with Reval, the Jessa Hospital and ZOL, we have the unique opportunity to combine basic research and clinical research and to translate acquired knowledge into clinical practice

Keywords

Advanced glycation end products, Angiogenesis, Cancer, Cardiovascular disease, Diabetes, Exercise intervention, Extracellular vesicles, Heart Ischemia, Ischemic stroke, Stem cells

Responsible

Annelies BRONCKAERS

Staff members

  • Ruth ACHTEN
  • Daniel AFRIFA
  • Sibel ALTINTAS
  • Myrte BARTHELS
  • Youri BEKHUIS
  • Amy BELBA
  • Edouard BENIT
  • Philippe BERTRAND
  • Virginie BITO
  • Annelies BRONCKAERS
  • Clément BRUNNER
  • Lise CARDINAELS
  • Nuran CAZ
  • Marithe CLAES
  • Guido CLAESSEN
  • William COLYN
  • Maarten CRIEL
  • Charlotte CUMS
  • Bart DE MOOR
  • Jarne DE PAEPE
  • Michiel DE WEVER
  • Sebastien DEFERM
  • Anouk DELAET
  • Boris DELPIRE
  • Dorien DELUYKER
  • Paul DENDALE
  • Lien DESTEGHE
  • Sebastiaan DHONT
  • Nathalie DIRKX
  • Pauline DREESEN
  • Jürgen DUCHENNE
  • Hanne EERDEKENS
  • Jonas ERZEEL
  • Maarten FALTER
  • Wouter FRANSSEN
  • Olivier GHEKIERE
  • Henri GRUWEZ
  • Wilfried GYSELAERS
  • Steffie HASEVOETS
  • Ellen HEEREN
  • Hein HEIDBUCHEL
  • Marc HENDRIKX
  • Lieven HERBOTS
  • Florian HERMANS
  • Sarah HOEDEMAKERS
  • Eline HOES
  • Ruben HOFFMANN
  • Baharak HOSSEINKHANI
  • Michiel JACOBS
  • Marc JANS
  • Arne JANSSEN
  • Hanne JEURISSEN
  • Hanne KINDERMANS
  • Sevda KIZILKILIC
  • Lieselotte KNAEPEN
  • Ruben KNEVELS
  • Joep KNOL
  • Pieter KOOPMAN
  • Koen KUIPERS
  • Ganesh KUMARASAMY
  • Yara LAMBRECHTS
  • Ivo LAMBRICHTS
  • Karen LIBBERECHT
  • Kaat MAESEN
  • Sandrina MARTENS
  • Jeroen MEBIS
  • Evelyne MEEKERS
  • Liesbet MESOTTEN
  • Jill MEYNEN
  • Joeri MEYNS
  • Luc MICHIELS
  • Sara MOURA FERREIRA
  • Amanda MOYA GOMEZ
  • Wilfried MULLENS
  • Ine NIESTE
  • Petra NIJST
  • Kim NIJSTEN
  • Rana ONDER
  • Bert OP 'T EIJNDE
  • Rik PAUWELS
  • Benjamin PETERS
  • Paula PINCELA LINS
  • Elke PIRLET
  • Laurent PISON
  • Laura PONSAERTS
  • Leen POPLEU
  • Thomas RAPS
  • Jolien ROBIJNS
  • David RUTTENS
  • Martijn SCHERRENBERG
  • Melanie SCHOUTTETEN
  • Senne SENECA
  • Gregory SERGEANT
  • Rob SIMONS
  • Christophe SMEETS
  • Jan STASSEN
  • Job STOKS
  • Mathieu STRUYVE
  • Monika STUDENNYKOVA
  • Kristof THEVISSEN
  • Anouck THIENPONT
  • Michiel THOMEER
  • Philippe TIMMERMANS
  • Jolien VAN DEN BOSCH
  • Kurt VAN DER SPEETEN
  • Sofie VAN DUFFEL
  • Marnicq VAN ES
  • Gregory VAN GENECHTEN
  • Lise VAN HOREBEEK
  • Evelyne VAN KERCKHOVE
  • Koenraad VAN RENTERGHEM
  • Vincent VANDENBOER
  • Wendy VANDENDRIES
  • Pieter VANDERVOORT
  • Tim VANGANSEWINKEL
  • Jen VANHERLE
  • Bert VANMIERLO
  • Lotte VASTMANS
  • Frederik VERBRUGGE
  • Steven VERMEULEN
  • Jan VERWERFT
  • Johan VIJGEN
  • Jens VOORTMANS
  • Pascal VRANCKX
  • Sarah WILLEMS
  • Esther WOLFS
  • Femke WOUTERS
  • Yuexi ZHUANG

Publications

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