Project R-10325

Neurological factors challenging bimanual motor control and treatment response in children with unilateral cerebral palsy (Research)

Children with unilateral Cerebral Palsy (uCP) present with many sensorimotor deficits in their impaired arm, compromising effective use in daily life activities. Accurate motor control between both arms is vital in performing bimanual tasks. This proposal is triggered by the need to provide well-targeted treatment plans optimizing bimanual motor control, as such improving the child's participation in daily life. Yet, bimanual motor control is not well understood and the brain dysfunctions challenging bimanual motor control in children with uCP have been poorly investigated. However, recent advancements in robotics and kinematics allow us to obtain finegrained information of how both arms are used together during complex bimanual tasks. In this project, we aim to improve our current understanding of bimanual motor control and treatment response in children with uCP. We will first acquire an in-depth quantification of bimanual motor control and, secondly, examine the role of neurological factors influencing bimanual motor control in children with uCP, i.e. structural connectivity of the corpus callosum, corticospinal tract wiring pattern and integrity of the sensory systems. Last, we will investigate the efficacy of an integrated somatosensory and bimanual motor therapy program and identify the best responders. Hence, the findings of this project will result in an advanced understanding of bimanual motor control, and contribute to tailor-made intervention programs.

01 January 2019 - 31 December 2022