Project R-9584

Autologous hematopoietic stem cell transplantation (AHSCT) in MS: a role for B cells? (Research)

Autologous hematopoietic stem cell transplantation (AHSCT) is a therapeutic option for MS patients refractory to conventional therapies. In recent years, evidence has accumulated for its high efficacy and decreasing mortality. Further, B cells are increasingly becoming recognized as key players in the pathological processes of MS. The effects of AHSCT in MS on B cells remain unknown. This project is aimed at biobanking peripheral blood of MS patients undergoing AHSCT at different time points before and after the procedure. B cell kinetics and function will be studied over the course of immune reconstitution. Our aim is to elucidate how B cells contribute to re-acquiring immune tolerance after AHSCT in MS. From a broader perspective, this study will help to elucidate the role of B cell immunobiology in MS.

01 January 2019 - 30 June 2022