Project R-11551

New insights in physical functioning in patients with COPD and lung cancer. (Research)

COPD and lung cancer are diseases with a high mortality. 5% of all deaths globally is caused by COPD and lung cancer is the leading cause of cancer death. Both diseases are characterized by extrapulmonary consequences. Muscle weakness, poor exercise tolerance, physical inactivity and a decrease in quality of life is seen in patients with COPD and lung cancer. The aim of this research is to provide more insight in these outcomes. In the first study we will compare stable COPD patients with patients during an acute (AE). Patients with an AE will also be followed prospectively during and one month after the hospitalization. Study aims are: (1) to investigate the prognostic value of assessment of physical functioning during AE in terms of hospital admission and mortality and (2) investigate the influence of AE on physical functioning and symptoms. In the second study we will included patients with a primary diagnosis of NSCLC who will undergo treatment. Assessments will be done before, during and after treatment. Study aims are: (1) to investigate physical functioning before start of treatment in lung cancer patients in comparison with healthy controls, (2) investigate changes in physical functioning and symptoms over the course of treatment in lung cancer patients and (3) investigate the relationship between physical status after treatment for lung cancer and comorbidities, hospitalizations and mortality. Assessments in both studies include tests to measure physical functioning (functional exercise capacity, muscle force, balance, physical activity) and questionnaires to measure symptoms.

01 February 2020 - 31 January 2024