Project R-11781

A search for the key to unlock the door towards enhanced quality of life after lung resection surgery in patients with non-small cell lung cancer: is it physical activity or physical fitness? (Research)

Non-small cell lung cancer (NSCLC) is a highly prevalent cancer type with poor prognosis. Nevertheless, a relevant proportion of patients has an extended survival nowadays due to improvements in treatment. Some small studies suggest that these patients have a decreased physical activity (i.e. all activities that a person performs during a day) and decreased physical fitness (i.e. the ability to perform activities). This is thought to negatively impact quality of life and longevity. First, this research proposal aims to investigate the impact of treatment for NSCLC (surgery, radiotherapy, chemotherapy, immunotherapy, targeted molecular therapy) on physical activity, physical fitness and its relationship with quality of life and symptoms across disease stages. We will conduct a large observational study in 120 patients (stratified for disease stage) in three centers using stateof- the-art methodology. Second, we aim to develop and evaluate targeted interventions (i.e. exercise training for physical fitness and tele coaching for physical activity) to enhance these outcomes, by means of two randomized controlled trials. In patients with early stage disease we aim to test both interventions and we will explore to what extent they have the potential to impact quality of life and symptoms. In patients with advanced disease – receiving palliative care – we will evaluate the impact of physical activity coaching on physical activity and decrease in function over time.

01 October 2021 - 30 September 2025