Project R-15458

Targeting the elongation of nutrition-derived fatty acids to promote central nervous system repair in multiple sclerosis (Research)

Phagocytes are important in the pathology of multiple sclerosis (MS) as they play a role in inflammatory processes and repair. Diet-derived fatty acids and their synthesizing enzymes are regulated during neuroinflammation and repair and provide novel targets to combat MS progression. In this project, the therapeutic potential of fatty acid-elongating enzymes and downstream lipid products are studied in in vitro and ex vivo models for inflammation and remyelination, and translated to the human setting using human iPSCs, human ex vivo models, and post-mortem MS lesions.

01 January 2025 - 31 December 2026