Project R-15928

A glitch in the matrix: collagen peptide supplementation to combat long-lingering muscle weakness upon anterior cruciate ligament reconstruction. (Research)

Patient with an anterior cruciate ligament (ACL) injury face a prolonged inability to return to work (~3 months) or sport (~9 months). Primarily due to long-lasting muscle weakness post-ACL reconstruction (ACLR), leading to functional impairments, accelerated development of osteoarthritis, and reduced quality of life. Recent data from our laboratory suggests that increasing muscle connective tissue protein synthesis during rehabilitation may be key to improve muscle function following disuse. Therefore, we will assess if collagen peptide (CP) supplementation, to stimulate muscle connective tissue protein synthesis, is a potent strategy to combatting muscular weakness following ACLR. In addition, we will perform a systematic review and meta-analyses to evaluate the impact of dietary interventions on ACLR rehabilitation (WP2), and a descriptive survey to assess supplement upon ACL reconstruction (WP3). Ultimately to improve patient care by assessing both the potential benefits of CP, as well as by identifying other supplements that are either beneficial or detrimental for muscle strength post-ACLR.

01 October 2025 - 30 September 2029