Project R-15859

Boosting polyphenol power: novel delivery strategies to enhance nuclear receptor-mediated gut and immune function (Research)

Polyphenols are natural compounds found in plant-based foods like berries, tea, and cocoa. They are known for their health benefits, such as reducing inflammation and supporting brain and gut health. However, their effectiveness is limited because only small amounts are absorbed by the body. This research aims to identify the most promising polyphenols and improve their absorption using advanced delivery systems like liposomes and nano-encapsulation. We will study how these optimized polyphenols interact with the gut, immune system, and gut bacteria using lab models, mice, and eventually in a human trial. By combining cutting-edge techniques such as metabolomics and microbiome analysis, we aim to understand how polyphenols can help control inflammation, improve nutrient absorption, and support overall metabolic and immune health. The goal is to create a science-based, effective dietary strategy that can prevent or reduce chronic inflammation and promote long-term health.

01 October 2025 - 30 September 2029