Project R-16064

In vitro stem cell based models to study nanoparticle effects on mitochondrial communication in neurodevelopment (Research)

This doctoral project investigates how nanoparticles affect early neurodevelopmental processes, with a particular focus on organelle communication. Mitochondria play a central role in stem cell fate decisions by regulating energy metabolism, calcium homeostasis, and signalling pathways that drive neural differentiation. Disruption of mitochondrial function and their crosstalk with other organelles, such as the endoplasmic reticulum, may represent an early and critical mechanism of neurodevelopmental toxicity. Zoology: Biodiversity and Toxicology (CMKDK) To address this, the research will develop advanced in vitro stem cell–based models to evaluate how nanoparticles alter mitochondrial dynamics, inter-organelle signalling, and downstream consequences for neural lineage commitment. The study combines detailed physicochemical nanoparticle characterization with molecular, imaging, and functional readouts, using both assay- and microscopy-based methods. By identifying mitochondrial and inter-organelle communication pathways that are vulnerable to nanoparticle exposure, this project aims to uncover early (neuro)developmental risks and support the safe-by-design development of nanomaterials, contributing to the proactive protection of sensitive populations.

16 September 2025 - 15 September 2029