Project R-16233

Ketones as a novel strategy to enhance muscle rehabilitation and training adaptations. (Research)

Periods of reduced muscle activity are inherent to many conditions (e.g., immobilization after an injury, bedrest due to illness). After just a few days, such inactivity will lead to reduced muscle mass and function, and ultimately to poorer metabolic health. Therefore, it is important to develop strategies that can mitigate these degenerative consequences and promote subsequent rehabilitation. With this project, we aim to investigate the effectiveness of ketone administration in (i) counteracting functional and molecular degeneration during immobilization, and (ii) promoting rehabilitation. This will be done specifically through interventional studies conducted in older adults and patients with anterior cruciate ligament injuries. The studies will combine physiological measurements (muscle strength, exercise capacity, etc.) and biochemical analyses of muscle and blood samples.

01 November 2025 - 31 October 2029