Project R-16246

Cognitive-Motor Interactions in Lateral Ankle Sprain and Chronic Ankle Instability: Integrating Brain Dynamics and Biomechanics Using Dual- and Multi-Task Paradigms (Research)

Lateral ankle sprain (LAS) is among the most common musculoskeletal injuries, with up to 40% of cases progressing to chronic ankle instability (CAI). CAI is characterised by pain, instability, proprioceptive deficits, and long-term limitations in daily and sport activities. Growing evidence shows that these problems extend beyond peripheral structures and involve altered central processing, increased visual dependency, and changes in motor-related neural activity. Yet, cognitive-motor interference (CMI) remains insufficiently explored. This project investigates cognitive-motor interactions in individuals with LAS and CAI by integrating neurophysiological, biomechanical, and cognitive-performance measures during dualand multi-task paradigms of increasing complexity (sitting, standing, walking, running, agility tasks). Using mobile brain imaging, 3D motion capture, an instrumented treadmill, and immersive virtual reality simulating real-world conditions, the study will examine event-related potentials (P100, P300), gait and balance adaptations, visual dependency, and psychological influences on performance. By identifying task-specific mechanisms of CMI and their impact on postural control and functional ability, this research will provide insight into brain–body dynamics in LAS and CAI and guide the development of cognitively enriched rehabilitation and return-to-sport strategies.

16 November 2025 - 15 November 2029