Project R-16268

Nano-WOUND: NANOvesicles for accelerated angiogenesis and WOUNDhealing (Research)

From minor cuts and scrapes to more serious injuries such as chronic wounds, diabetic ulcers, and burn injuries, the experience of dealing with wounds is something that every person on Earth shares. As chronic and severe wounds can lead to prolonged suffering, infections, scarring, tissue damage and significant healthcare costs, the desire to expedite the healing process is paramount. Recent advancements in nanotechnology have opened up new avenues for biomedical research, particularly in the field of regenerative medicine. In this study, I will develop a novel strategy for promoting wound healing based on nanoghosts (NGs), which are vesicles of nanometer range that technologically reconstructed from the cytoplasmic membranes of cells. These NGs will serve as carriers for a specific microRNA (miRNA) payload, which will enhance blood vessel formation and thereby accelerate wound healing. The developed NGs will be tested in relevant cell models but also in mice and a wound model based on human skin. My project will result in well-designed, tissue-specific NGs capable of accelerating wound healing, laying the groundwork for future clinical trials. This will not only improve quality of life for those with chronic wounds but also alleviate the pain and discomfort associated with prolonged healing periods.

01 November 2025 - 31 October 2029