Project R-3572

Title

The role of microglia during the development of neuronal networks in the embryonic central nervous system

Abstract

Microglia are considered to be the resident macrophages of the central nervous system (CNS) and are responsible for the protection against infections and injuries by using phagocytosis, the secretion of cytokines and the presenting of antigens. There is growing evidence that, in addition to this protective role, the microglia also take on other functions in the developing and adult CNS, like the phagocytose of dead cells, the elimination of axonal extensions, neuronal growth and synaptogenesis. Microglia colonize at crucial times and locations during the development of the embryonic CNS. This colonization coincides with the period when the neuronal migration peaks and the synaptogenesis and differentiation of neurons is in progress.

Period of project

01 January 2012 - 31 December 2013