Ivo Lambrichts - Laboratory for Histology and Regeneration (HISTOREGEN)



Prof. dr. Ivo Lambrichts, DDS

Stem cells
Tissue regeneration
Oral pathology


+32 (11) 26 92 45


Orcid id 
Research gate


My research contributes the field of head and neck pathology and tissue regeneration.  We use neural crest derived cells, 3D printed implants, hybrid organoids and scaffolds. I was member of the research team that developed and implanted the world first 3D printed custom made titanium implant. I contributed to 194 A1 publications and guided over 22 PhD students as a (co)promotor.  In 2020,  I was granted the “Distinguished Scientist Award on Pulp Biology and Regeneration” from the International Association for Dental Research, Alexandria, USA.

Core Techniques

  • Light microscopy
  • Virtual microscopy
  • Electron microscopy
  • Mineralised tissue microtomy and bone implant interface
  • Cone beam CT – High Resolution MRI –Histology matching
  • 3D printing (CaP, Ti)


Key Publications

  1. Driesen RB, Hilkens P, Smisdom N, Vangansewinkel T, Dillen Y, Ratajczak J, Wolfs E,Gervois P, Ameloot M, Bronckaers A, Lambrichts I. Dental tissue and stem cells revisited:New insights from the expression of fibroblast-activation protein-alpha. Front Cell Dev Biol. 2020;7:389. (IF 2020: 5.186)
  2. Lo Monaco M, Gervois P, Beaumont J, Clegg P, Bronckaers A, Vandeweerd J-M, Lambrichts I. Therapeutic potential of dental pulp stem cells and leukocyte- and platelet-rich fibrin for osteoarthritis. Cells 2020;9:980 (IF 2020: 4.366)
  3. Lambrichts I, Driesen RB, Dillen Y, Gervois P, Ratajczak J, Vangansewinkel T, Wolfs E,Bronckaers A, Hilkens P. Dental pulp stem cells: Their potential in reinnervation and angiogenesis by using scaffolds. J Endod. 2017;43:S12-S16. (IF 2017: 2.886)
  4. Gervois P, Wolfs E, Dillen Y, Hilkens P, Ratajczak J, Driesen RB, Vangansewinkel T, Bronckaers A, Brône B, Struys T, Lambrichts I. Paracrine Maturation and Migration of SH-SY5Y Cells by Dental Pulp Stem Cells. J Dent Res. 2017;96:654-662. (IF 2015: 4.602)
  5. Martens W, Sanen K, Georgiou M, Struys T, Bronckaers A, Ameloot M, Phillips J, Lambrichts I. Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct invitro. FASEB J. 2014;28:1634-43. (IF 2014: 5.299)