STRUCTUROMICS

The global pursuit of good health and well-being faces a significant challenge from the rising prevalence of non-communicable diseases, particularly in an ageing population. In the EU, the majority of healthcare expenditures is dedicated to chronic conditions, reflecting a growing burden of chronic diseases and co-morbidities. In Belgium, recent statistics highlight the prevalence of multiple chronic conditions among older adults. To address these challenges, a transformation of healthcare is essential, encompassing prevention, diagnosis, and therapy, rooted in a holistic understanding of human biology. Biological phase separation, a key aspect of cellular processes, plays a vital role in essential functions like signalling, gene regulation, and protein assembly. Dysregulation of phase separation and protein structure is linked to numerous chronic diseases. However, current research lacks an interdisciplinary approach and a technology platform for a detailed understanding of protein condensates. The proposed research, termed "structuromics," is a forward-looking approach that integrates molecular analysis, modern technology, and theory to advance our understanding and treatment of various diseases. Focusing on tauopathy, the abnormal accumulation of Tau protein in neurons associated with chronic diseases such as Alzheimer's and Pick's disease, the proposal aims to bridge gaps in technology, methodology and knowledge, and develop innovative solutions for tackling these pressing health challenges.