Equipment
Our microscopes include widefield, TIRF, super-resolution, lightsheet and point scanning confocal with nonlinear optics instruments. The setups are equipped for live-cell imaging, FRET, Ca2+ imaging, slide scanning, label-free imaging, FRAP/photo-activation and more. We can accommodate a range of samples, from single molecules over cells and tissue sections to centimeter large specimens.
Microscopes
Zeiss Elyra PS.1
Perform fast, live-cell fluorescence imaging experiments on this powerful widefield fluorescence microscope with TIRF and 3D super-resolution (SIM and SMLM) capabilities. This commercial Zeiss microscope is equipped with 4 laser lines (405, 488, 561 & 642nm), an incubation chamber, a dedicated SIM camera and SMLM camera, Definite Focus system and piezo stage. Additionally, the microscope is combined with a patch clamp setup allowing simultaneous fluorescence and electrophysiology recordings.
Widefield - TIRF - super-resolution
Zeiss LSM880 NLO AiryScan
Use this highly versatile state-of-the-art confocal microscope to solve all your multi-dimensional research questions. Equipped with an NLO module for deep-tissue and label-free imaging, pulsed excitation and time-resolved detection for FLIM, a spectral detector, and an AiryScan detection system for super-resolved fluorescence microscopy, the LSM880 provides a convenient solution for most of your imaging needs.
Confocal - two-photon - label-free - correlation - super-resolution - spectral detection
Zeiss LSM900 Airyscan 2
Use this highly versatile state-of-the-art confocal microscope to solve all your multi-dimensional research questions. Equipped with sensitive GaAsP PMT detectors, flexible variable beam splitter dichroics and the latest Airyscan 2 detection system for super-resolved fluorescence microscopy, the LSM900 provides a convenient solution for most of your imaging needs. Additionally, the AI Sample Finder and advanced Navigation and Tiles module make it very easy to find regions of interest and set up your imaging experiments.
Confocal - multidimensional - correlation - super-resolution
Zeiss Lightsheet 7
Use the Lightsheet 7 for fast volumetric imaging of sensitive samples such as living model organisms and organoids, or image large cleared samples as a whole with sub-cellular details. The fully incubated microscope has 5 laser lines spanning the visible spectrum and is equipped with two cameras for simultaneous dual-color acquisitions. A broad range of objective lenses and sample chambers can accommodate almost any sample.
Light sheet - volumetric (3D) imaging - gentle illumination
Nikon Eclipse Ti2-E
This fully motorized microscope with an exceptional field-of-view is equipped with a powerful multicolor LED lightsource and a Photometrics Kinetix camera for very fast imaging of large sample areas, making it the perfect match for all your functional imaging needs.
Widefield - LED excitation - fast - big FOV
Homebuilt smFRET
Homebuilt dedicated 483/635-nm alternating excitation, dual-color dual-polarization detection confocal microscope. This system allows imaging more than 20 parameters per single molecule, making it the ideal system for subnanometer accurate single-molecule FRET studies.
Pulsed Interleaved Excitation (PIE) - single-molecule FRET - single-molecule fluorescence - FCS
Zeiss Axioscan Z.1
Increase the throughput of your experimental workflow with this fully automated whole slide scanner. Equipped with a multicolor LED lightsource, high resolution lenses, automated focussing and positioning control, and high quality detection optics, the upright microscope captures brightfield and fluorescence images of outstanding quality. The ZEN software suite allows simple and automated digitization of your (large) samples.